For instance, for breast cancer risk, Lu et al. estimated an OR of 4.00 [95% CI: 2.04–8.73] for CHEK2 c.1100delC and an OR of 1.42 [95% CI: 0.76–2.81] for all other CHEK2 pathogenic variants in their study of 11,416 affected women16 and Dorling et al. estimated an OR of 2.66 [95% CI: 2.27–3.11] for CHEK2 c.1100delC and an OR of 2.13 [95% CI: 1.60–2.84] for all other CHEK2 pathogenic variants in the population-based setting of their study10. Here, CHEK2 is linked to breast cancer.