BRCA1 and breast cancer: We found evidence of association with breast cancer risk for four genes, with estimated adjusted ORs of 5.3 [95% CI: 2.1–16.2] for BRCA1, 4.0 [95% CI: 1.9–9.1] for BRCA2, 3.4 [95% CI: 1.4–8.4] for ATM and 4.3 [95% CI: 1.0–17.0] for PALB2 (Table 2, Fig. 2).