HMGA1 and central nervous system cancer: QPCR showed that both HMGA1 and MYH9 mRNA levels were upregulated in glioma tissues compared to normal brain tissues (NB), and overexpressed levels of HMGA1 and MYH9 in glioma patients were positively correlated with pathological classification (WHO 2 vs. WHO 3 vs. WHO 4) (P < 0.05) (Fig. 1A and B).