miR-424-5p is abnormally expressed in many types of tumors, such as thyroid cancer [41], intrahepatic cholangiocarcinoma [42], breast cancer [43], ovarian cancer [44], colorectal cancer [45], etc. However, it plays two different roles in different tumors: oncogene or tumor suppressor gene. The gene discussed is ENSG00000280371; the disease is colorectal cancer.