CFTR and autosomal dominant polycystic kidney disease: The alterations in modulation of energy production and utilization in ADPKD are dependent on several inner cellular signaling pathways, such as AMP-activated protein kinase (AMPK), calcium signaling at mitochondria-associated membranes, mammalian target of rapamycin complex 1 (mTORC1), cAMP, and cystic fibrosis transmembrane conductance regulator (CFTR)-mediated ion transport [23, 24].