Meanwhile, 19 genes were also selected according to the harmfulness of mutation, including MUTYH, USH2A, HBS1L, GLI3, SBDS, SND1, ABCA2, RPS6KA4, FLVCR1, ATIC, SCN11A, ATP6V1A, GLRA1, PRMT8, PKD1, INSL3, SUPT5H, NCF4, and GPR143. To study the relationship between those gene mutations and ADPKD, we first analyzed the effects of gene mutations on proteins. Here, RPS6KA4 is linked to autosomal dominant polycystic kidney disease.