The enrichment analyses of the 117 miRNA–mRNA pairs showed that they were predominantly involved in negative regulation of cellular component organization, response to organic substance in GO-BP category; eukaryotic translation initiation factor 4F complex, and nuclear body in GO-CC category; SNAP receptor activity, protein complex binding, protein tyrosine phosphatase activity under GO-MF category, as well as KEGG pathways associated with renal cell carcinoma signaling, prolactin signaling and NFR2-mediated oxidative stress response. This evidence concerns the gene PRL and hereditary clear cell renal cell carcinoma.