Our previous reports in accordance with other papers indicated that EVO was shown to arrest cell cycle progression at the G2/M phase and induce apoptosis in various cancer cells including colon carcinoma, glioblastoma, and ovarian cancer cells, and the mechanism including activation of endoplasmic reticular (ER) stress and c-Jun N-terminal kinase (JNK) was identified [26, 30]. The gene discussed is MAPK8; the disease is colon carcinoma.