Our recent studies demonstrated that EVO was able to inhibit the proliferation of human renal cancer cells, glioblastoma cells, and colorectal carcinoma cells, and activation of protein kinase RNA (PKR)-like endoplasmic reticulum (ER) kinase (PERK), and c-Jun N-terminal kinase (JNK) is identified [24–26]. Here, MAPK8 is linked to glioblastoma.