In another study, researchers showed that Mps1 overexpression is a poor prognostic marker for neuroblastoma patients, and incubation of neuroblastoma cell lines with Mps1 inhibitors reversine and Mps-BAY2 leads to polyploidization/aneuploidization of the cells before they undergo mitotic catastrophe [68]. The gene discussed is TTK; the disease is neuroblastoma.