AKR1C3 and breast cancer: In order to verify the correlation between hub gene and TAM resistance in breast cancer, this study imported hub gene into GSCALite database for analysis, the results showed that AKR1C1, AKR1C2, AKR1C3 and FN1 genes were related to tyrosine kinase inhibitors, EGFR inhibitors, MEK inhibitors, proteasome inhibitors, folic acids resistant, pyrimidines resistant and other drug resistance (Fig. 6), suggesting AKR1C1, AKR1C2, AKR1C3, FN1 and other genes have multidrug resistance, but the database does not include the situation of TAM resistance.