ESR1 and breast cancer: It has been reported that the abnormal expression of STAT1 [23–25], ESR1 [26, 27], CYP1B1 [28, 29], FN1 [30] and UGT1A family genes [31, 32] is closely related to breast cancer and TAM multidrug resistance, while the relationship between AKR1 family and breast cancer and TAM resistance has not been studied.