It has been reported that the abnormal expression of STAT1 [23–25], ESR1 [26, 27], CYP1B1 [28, 29], FN1 [30] and UGT1A family genes [31, 32] is closely related to breast cancer and TAM multidrug resistance, while the relationship between AKR1 family and breast cancer and TAM resistance has not been studied. Here, STAT1 is linked to breast cancer.