Recently the beneficial role of the hematopoietic-restricted deletion of S100A8 and S100A9 in preventing monocytosis has been reported [17], while Yamaoka et al., hypothesized that the S100A8 gene might be involved in the development of atherosclerosis [26]; therefore, we speculate that the higher expression of the S100A8 gene in insulin resistance independent of the WBC profile, may be of importance in the etiology of atherosclerosis. Here, S100A8 is linked to Insulin resistance.