S100A9 and Insulin resistance: Recently the beneficial role of the hematopoietic-restricted deletion of S100A8 and S100A9 in preventing monocytosis has been reported [17], while Yamaoka et al., hypothesized that the S100A8 gene might be involved in the development of atherosclerosis [26]; therefore, we speculate that the higher expression of the S100A8 gene in insulin resistance independent of the WBC profile, may be of importance in the etiology of atherosclerosis.