MTHFR and hyperhomocysteinemia: We observed that 15% of women had hyper-homocysteinemia and a high percentage were heterozygotes (C677T 36.4%; A1298C 17.5%) and homozygotes (C677T 18.6%; A1298C 5.2%) for rare alleles of MTHFR polymorphisms, beyond high percentage of smokers (26%).