CASP1 and breast cancer: BBR also increases the release of Lactic Acid Dehydrogenase (LDH) in the MDA epithelial human breast cancer cell line (MDA-cells) and downregulates the purinoceptor 7 (P2 × 7) associated with speck apoptosis, procaspase-1, and caspase-1 p20, domain recruitment (ASC), IL-1β proteins, interleukin-18 (IL-18), the mRNA expression of caspase-1 and ASC in the NOD-, and LRR- and the pyrin domain-containing protein 3 (NLRP3) inflammasome cascade [55].