Similarly, Kou et al. demonstrated that BBR decreases the migration and invasion of melanoma cells B16 cells and diminishes the expression levels of RARα (retinoic acid receptor-α), p-AKT, and p-PI3K while upregulating the expression levels of RARβ (retinoic acid receptor-β) and RARγ (retinoic acid receptor-γ). This evidence concerns the gene AKT1 and melanoma.