SNCA and Parkinson disease: A multiple-ascending dose in a Phase 1b clinical trial of PRX002, consisting of three infusions on a monthly basis, also showed a promisingly high level of target engagement, once again with a 95.5% reduction in serum alpha-synuclein and BBB penetration, with dose-dependent rises of the PRX002 measurements of CSF in a sporadic PD cohort (n = 80) [65].