The pathological aggregation of alpha-synuclein has been implicated in the etiology, pathogenesis and progression of several neurodegenerative diseases, including familial and sporadic forms of Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), that have coalesced into a group of alpha-synucleinopathies [1,2]. The gene discussed is SNCA; the disease is Lewy body dementia.