The pathological aggregation of alpha-synuclein has been implicated in the etiology, pathogenesis and progression of several neurodegenerative diseases, including familial and sporadic forms of Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), that have coalesced into a group of alpha-synucleinopathies [1,2]. This evidence concerns the gene SNCA and multiple system atrophy.