The production of AFGuan leads to a guanine to thymine substitution in the third base of codon 249 of the host DNA, which is the main basis of the carcinogenic effect of AFB1, as this mutation is responsible for the loss of function of the p53 gene, a trigger for hepatocellular carcinoma (HCC) [9]. The gene discussed is TP53; the disease is hepatocellular carcinoma.