These substituted rhodanines have been discovered and reported for several pharmaceutical applications, including topoisomerase II inhibition potency [3]; potential AChE inhibitors [4,5]; HIV-1 integrase inhibitors [6]; anti-cancer agent towards MCF-7 breast cancer cells [7] and anti-diabetic (T2DM) targeting the inhibition of enzymes such as aldose reductase (ALR) [8], α-glucosidase [9], α-amylase [10] and PTP1B enzyme [11], and other therapeutic targets have also been reported, such as antibacterial ones [12]. This evidence concerns the gene ACHE and cancer.