ACE and major depressive disorder: Several pharmacological activities and properties of C. monogyna include hypotensive [81], hypolipidemic and antioxidant activity, [66,82,83,84,85], angiotensin-converting enzyme (ACE) inhibition [86], cardioprotective effects [87,88], anti-anxiety and anti-depression [89], adverse chronotropic and cardiotonic effects [90], protection against myocardial infarction [91], free-radical-scavenging, anti-inflammatory, gastroprotective and antimicrobial activities [67], inhibition of thromboxane A2 [92] and immunological activity [93] (Table 1).