In colorectal cancer cells, α-mangostin increases the protein levels of the proapoptotic molecules tumor suppressor protein p53, the pro-apoptotic BCL2 gene family member BAX (BAX), poly (ADP-ribose) polymerase (PARP), and the release of Endonuclease-G (Endo-G) from the mitochondria. The gene discussed is ENDOG; the disease is colorectal cancer.