Flozins may bring positive effects in T2DM, atherosclerosis, and cognitive impairment through several mechanisms, including anti-inflammatory and anti-atherosclerotic properties, SGLT1 inhibition, AChE inhibition, reduction in oxidative stress, amelioration cerebrovascular remodeling and restoring a balance between catabolism and anabolism. Here, SLC5A1 is linked to Cognitive impairment.