GPX4 and non-small cell lung carcinoma: In our previous study, we observed that AS alone could inhibit NSCLC growth through distinct cell death modes depending on the cell line, with concomitant generation of cellular ROS level, induction lipid peroxidation, and reduction in glutathione peroxidase 4 (GPX4) expression selectively in A549, while having triggered caspase-dependent apoptosis in H23 cells.