Of the seventeen nitrogen-containing heterocyclic compounds 22–38, four of them (30, 31, 32, and 33) which are 1,2,3-triazole derivatives, were potent against cyclooxygenase-2 (COX-2) and 15-lypoxygenases (15-LOX) at sub-micromolar and micro molar concentrations, respectively, with only 31 and 33 showing activity against tumor associated carbonic anhydrase enzymes [51]. Here, PTGS2 is linked to neoplasm.