Nagilactone E, 157, a dinorditerpenoid isolated from Podocarpus nagi [240] upregulates the expression of programmed death-ligand 1 (PD-L1) in lung cancer cells through the activation of jun N-terminal kinases (JNK)-c-Jun axis, which has the potential to combine with the PD-1/PD-L1 antibody therapies in lung cancer [240]. The gene discussed is MAPK8; the disease is lung carcinoma.