AKT1 and cancer: Anti-proliferative and cancer preventing properties of compound 143 and its derivative fucoxanthinol, 144 are mediated through different signaling pathways, including the caspases, Bcl-2 proteins, MAPK, PI3K/Akt, JAK/STAT, AP-1, GADD45, and several other molecules that are involved in cell cycle arrest, apoptosis, anti-angiogenesis, or inhibition of metastasis (Figure 32) [214].