In the brain of patients with AD, immoderate reduction in acetylcholine (ACh) hydrolyzed by acetylcholinesterase (AChE) is one of the essential elements in the development of dementia, and an approach in this regard could be through the inactivation of AChE activity, a critical enzyme that cleaves synaptic ACh and stops neuronal signals [3]. The gene discussed is ACHE; the disease is dementia.