IL6 and cancer: In our previous studies, we have shown that the polyphenols of plant origin contained in the extract from the flesh of Annurca apples and lemon (Citrus limon) peel extracts (LPE) are able to reduce the migration/invasiveness induced by IL-6 or on the up-regulation of MMP-9/2 in MKN-28 and AGS cancer cells [24,29].