Since STAT3 phosphorylation is a crucial event in the signaling pathway, triggered by IL-6 in MMP-2 up-regulation in gastric cancer cells [20,33], we analyzed the STAT3 phosphorylation status following the rIL-6 exposure before and after preincubation with LPE in T88 and T93 cells. This evidence concerns the gene STAT3 and gastric cancer.