MYCN and cancer: It induces apoptosis and inhibits cell proliferation, migration, and invasion in a dose-dependent manner in many human cancer cell lines [8], Uhl et al. tested the antiproliferative activity of this natural compound on four human NB cell lines, in particular SKNBE and KELLY (MYCN-amplified), and SKNAS and SKNFI (MYCN-non-amplified).