BRAF and metastatic melanoma: The azetidine-containing cobimetinib (GDC-0973, RG7420) (40 in Figure 5) is a MEK inhibitor by Exelixis and Genentech (Roche) approved by the FDA and EMA in 2015 for the treatment of metastatic melanoma expressing BRAF V600E or V600K mutation as a combination with vemurafenib [172].