According to the findings of this study, the majority of BSCs had underlying PTCH1 and SMO mutations in addition to mutations in other known BCC drivers such as MYCN, PPP6C, GRIN2A, CSMD3, DCC, PREX2, APC, PTEN, and PIK3CA [30]. The gene discussed is PTCH1; the disease is skin basal cell carcinoma.