ATG3 and acute myeloid leukemia: As AML cells heavily rely on OXPHOS for cell survival and were shown to be particularly sensitive to mitochondria damaging agents [73,74,75,76], we observed increased sensitivity of ATG3-deficient AML cells to OXPHOS inhibiting drugs oligomycin and antimycin A whereas ATG3-depleted AML cells were resistant glycolysis inhibition (Figure 5C).