Furthermore, the immunocompromised BM microenvironment is aggravated by MM cell-induced abnormal increased Treg cells, MDSCs, OCs, and/or Breg cells, as well as upregulation of their secretory immunosuppressive cytokines, i.e., IL-6, IL-10, and TGFβ. The gene discussed is TGFB1; the disease is Miyoshi myopathy.