VEGFA and colon adenocarcinoma: While IL-17A-overexpressing murine fibrosarcoma and colon adenocarcinoma showed enhanced tumor growth with increased vascular density, IL-17A was shown to induce the production of various angiogenic factors including vascular endothelial growth factor (VEGF), prostaglandin E2, CXCL1, and nitric oxide by tumor cells and fibroblasts [118,119].