PADI4 and neoplasm: Utilizing genetically altered PAD4 KO mice, a key enzyme that regulates NETs formation, or treatment with DNAse in an orthotopic ovarian tumor model significantly reduced omental metastasis by 70%, thus indicating the early onset of tumor progression, especially for those with high metastatic potential, through the induction of NETs in the premetastatic omental niche, which, in turn, facilities distant tumor metastasis (Figure 1).