Here, we found that parental PANC-1 cancer cells as well as PANC-1 CSCs accumulated the fluorescent edelfosine analog Et-BDP-ET [1-O-[11′-(6〳-ethyl-1〳,3〳,5〳,7〳-tetramethyl-4〳,4〳-difluoro-4′′-bora-3a′′,4a′′-diaza-s-indacen-2〳-yl)undecyl]-2-O-methyl-rac-glycero-3-phosphocholine] [47] in the ER (Figure 5a), labeled with a baculovirus-based reagent using the ER signal sequence of calreticulin and KDEL (see Materials and Methods). The gene discussed is CALR; the disease is cancer.