Here, we found that the alkylphospholipid analog edelfosine accumulates in the ER of different human pancreatic cancer cell lines [29] (this work) and in human pancreatic CSCs (this work), mounting a persistent ER stress response, as assessed by a dramatic and sustained CHOP upregulation, that eventually leads to apoptosis. The gene discussed is DDIT3; the disease is familial pancreatic carcinoma.