HMGCR and cancer: We further verified the expressions of the oxidative stress-responsive genes and the cholesterol biosynthesis-related genes using qPCR in the GBM cancer cells and recorded an increase in the mRNA levels of HMGCR, HMCGS1, DHCR24, GSR, GSTM2 and GCLC after MPT0L145 treatment in U87MG and M059K cells (Figure 4F).