In contrast to the inhibitory effect of NDRG2 on ubiquitin-protein ligase, a recent report demonstrated in colitis and colitis-associated tumors that NDRG2 enhances the interaction of the E3 ligase FBXO11 with Snail, the repressor of E-cadherin, to promote Snail degradation by ubiquitination and to maintain E-cadherin expression [27]. The gene discussed is FBXO11; the disease is colitis.