TNF and neoplasm: Previous findings regarding CD8+ T-cell polyfunctionality [12] were confirmed with enhanced E7-specific CD8+ T-cell infiltration into the tumor along with enhanced E7-specific CD8+ T-cell polyfunctionality, defined by the simultaneous expression of IFN-γ, TNFα and the degranulation marker CD107α along with a less exhausted phenotype (CD8+ PD1+ Tim3+) (Figure 2D and Figure S2A).