Moreover, Y. Shen et al. established that on the treatment of EC cell lines with MEK inhibitor RG7420, MALAT1 can decrease up to 6.13 times with upregulation of tumor suppressor miR-129-5p and downregulation of TAK1, leading to decreased metastasis and increased apoptosis of EC cells [200]. Here, MALAT1 is linked to neoplasm.