H19 and cancer: Furthermore, S. Yu et al. studied that H19 is also related to the chemo-resistance mechanisms in choriocarcinoma cells, and they found that, after knock out of H19 from JEG-3/5-FU and JEG-3/MTX cells, the drug resistance index was diminished, leading to significantly reduced cancer proliferation, invasion, and migration with simultaneously increased apoptosis [170].