HMGA2 and breast cancer: Similarly, in a recent study that evaluated normal and BC tissues of 15 patients, HOTAIR has been reported to promote BC development and migration through upregulation of either BCL-W (an anti-apoptotic protein) via miR-206 sequestering (p < 0.001) [107], SOX2 via epigenetic suppression of miR-34a [53], HMGA2 via miR-20a-5p suppression [108], ZEB1 via miR-601 sponging [109], or by regulating a broad spectrum of various other miRNAs as well.