RELA and ependymoma: Contrary to the initial hypothesis positing that the RELA partner drives the transcriptional activity of RELA fusion proteins, recent chromatin interaction-based analyses support the idea that it is the ZFTA moiety that shuttles the RELA component to the nucleus and dictates the RELA fusion binding affinity across the genome, so as to orchestrate the transcription of ependymoma-associated genes in collaboration with RELA targets [105,106,107,108].