AKT1 and cancer: Phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB, also known as Akt), the mammalian target of the rapamycin (mTOR) signaling pathway, is vital for the regulation of cell biological functions in cancers, including cell proliferation, metastasis, cell apoptosis, autophagy, and glucose and lipid metabolism [81,82,83].