Upregulation of PCAT6 can interact with insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) and insulin like growth factor 1 receptor (IGF1R) to stabilize IGF1R mRNA and activate the downstream signaling pathways, including PI3K/Akt signaling and NF-κB signaling, which ultimately facilitate tumor growth and BM (Figure 2) [53]. The gene discussed is AKT1; the disease is neoplasm.