MYC and cancer: We conclude that the MYC level-associated genes identified in this study, and particularly the 1886 genes making up clusters c7, c9 and c10, cross-validate well in relation to genes that change during lymphoma development in the Eμ-Myc in vivo lymphoma model as well as human signature genes that are characteristic for a wide range of human cancers with highly de-regulated MYC expression and high MYC levels as a negative prognostic factor.