In the present study, we use a transduced primary B-cell model of MYC-driven B-cell lymphoma to identify genes that are regulated as essentially normal murine B cells that transform into lymphoma-like cells in response to progressively increasing MYC levels and further to identify how the lymphoma-associated T58A and T58I mutations affect this transition in terms of altered gene expression programs. The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.