MYC and cancer: Efforts have also been made to identify genes that are directly regulated by MYC by combining gene expression profiling with chromatin immunoprecipitation in a B-cell line [20], or, more recently, identifying a list of 100 direct MYC targets and subsequently validating these targets across an array of human cancers by employing techniques for rapid induction of MYC degradation in combination with RNA-seq of nascent RNA [21].