IDH2 and central nervous system cancer: In IDH-wildtype gliomas, the immunosuppressive genes that showed a statistically significant difference in expression between NHMP and HMP samples were PD1 and PDL1 (median PD1: 0.19 versus 0.08, p = 0.04; PDL1: 1.06 versus 0.27, p = 0.04) (Figure 3D).