Most of the immune cell infiltration scores for CD8 T cells, CD4 T cells, subtypes of dendritic cells, and macrophages were higher in IDH-wildtype samples compared to IDH-mutant samples (Figure 2E and Figure S1), which is similar to previous findings in primary gliomas from The Cancer Genome Atlas (TCGA) dataset [17]. This evidence concerns the gene IDH2 and central nervous system cancer.