It is important to define pathological parameter of response, currently considered as follows: Ef0, no necrosis of tumour cells; Ef1, some necrosis of tumour cells with more than one-third of viable tumour cells; Ef2, less than one third of viable tumour cells; Ef3, no viable tumour cells viable (complete pathological response). The gene discussed is EEF2; the disease is neoplasm.