TP53 and intestinal type adenocarcinoma: In addition, recurrent somatic variants including KRAS, TP53, CDKN2A, NFE2L2, PIK3CA, NOTCH1 and PIK3R1 were already described in SNSCC [27], whereas TP53, CDKN2A and KRAS mutations were recurrent in intestinal-type adenocarcinoma (ITAC) [28].