In addition, potentially targetable mutations in PIK3CA, FGFR2, FGFR3, BRAF, HRAS, MAP2K1, PTEN, and NOTCH1 were found and could be associated with progressive disease [75], but further analyses are needed in sinonasal carcinomas. The gene discussed is NOTCH1; the disease is nasal cavity and paranasal sinus carcinoma.