FN1 and familial pancreatic carcinoma: In this work, we investigated, for the first time, the impact of in vitro hypoxia (5% O2) on the radiation treatment response of pancreatic cancer cells (PANC-1) in our recently developed polymer (polyurethane) based highly macro-porous 3D scaffold, which is surface modified with proteins (fibronectin) for better ECM mimicry [27].