FN1 and neoplasm: This large increase in ECM protein deposit (i.e., collagen, fibronectin, and laminin) and tumour stiffness, along with very high cancer cell growth, influences pro-survival characteristics and causes intra-tumoral blood vessel disruption and collapse, consequently impairing (chemotherapeutic) drug delivery (resulting in chemo-resistance) and causing heterogeneous expanses of low oxygen gradients (hypoxia) [9,13,14,15,16,17,18].