CAV1 and familial pancreatic carcinoma: For example, Hehlgans et al. (2009) utilised a spheroid 3D model for the pancreatic cancer cell line MiaPacCa2 treated with 0–6 Gy of irradiation to identify Caveolin-1 and TAE226 as potential radiosensitisers using a two day post treatment timeframe.