Compared to normal bladder tissue, regulators with CNV gain, such as ATG7, PHKG2, CA9, OTUB1 and PML, were markedly highly expressed in BLCA tissues, while regulators with CNV loss, such as ATM, CISD1 and CDO1, were markedly lower in BLCA tissues. Here, CISD1 is linked to bladder transitional cell carcinoma.