HIF1A and metastatic neoplasm: Significant associations between the HIF1 overexpression and patient mortality have been shown in various cancer types, including breast [182,183] and cervix cancer [184,185], non-small cell lung cancer [186], sarcoma [187], etc. Moreover, HIF1 activation increases the expression of proangiogenic genes, for example, the vascular endothelial growth factor, which is associated with metastatic disease [188].