TAMs affect many different aspects of the tumor cell behavior by producing growth factors, such as epidermal growth factor (EGF), fibroblast growth factors (FGF), vascular endothelial growth factor (VEGF) [247], as well as due to the production of cytokines capable of activating pathways that control apoptosis and cell proliferation through the modulation of certain genes. The gene discussed is EGF; the disease is neoplasm.