HIF1A and neoplasm: In Figure 5, it has been shown that due to the activation of a number of signaling factors, in particular, p53, TNFα, NF-κB, HIF1α, VEGF, etc., the reactive oxygen species contribute to the activation of downstream pathways phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and RAS/MEK/ERK (ERK/MAPK), which leads to the transformation of a healthy cell into a tumor, as well as cell survival and hyperproliferation, avoidance of apoptosis, invasion, metastasis, and angiogenesis [140,141,142].