CD8A and neoplasm: Depending on the tumor stage and the function performed, tumor-associated neutrophils are divided into three subgroups [252]: (1) High-density neutrophils and (2) low-density neutrophils with an antitumor effect, as well as (3) granulocytic-myeloid derived suppressor cells (G-MDSC), which due to the production of reactive oxygen species inhibit the activity of cytotoxic CD8+ lymphocytes, promoting tumor growth and progression (Figure 8) [253].