AKT1 and non-small cell lung carcinoma: NOX4 is also highly expressed in non-small cell lung cancer (NSCLC) and promotes cancer progression by inducing glycolysis during c-Myc activation via the ROS/PI3K/Akt pathway, while GKT137831, a selective NOX4 inhibitor, suppresses the growth of tumor cells both in vitro and in vivo [101].