NOS2 and neoplasm: The increased iNOS activity was also found in tissue samples of colorectal cancer [119], which plays a crucial role in the angiogenesis of this type of neoplasm [120], in patients with bladder cancer [121], who are accompanied with high NO levels in tumor tissues, urine, and blood serum [52,122], with pancreatic cancer [123], non-small-cell lung carcinoma [124], as well with head and neck squamous carcinoma [125], glioblastoma [126], and melanoma [127].