CXCL1 and neoplasm: For instance, it was found that the chemokines C-X-C motif ligand 1, 2, 3, and 8 (CXCL1, CXCL2, CXCL3, and CXCL8) are overexpressed in melanomas, which is accompanied by increased proliferation of tumor cells and tumor metastasis [306,307].