SETD2 and cancer: As shown in Figure 1, our analysis of a few epigenetic regulating genes, such as SETD2, HDAC1, TET2 and EZH2, using The Cancer Genome Atlas (TCGA) Pan Cancer dataset on cBioPortal for Cancer Genomics (https://www.cbioportal.org/, accessed on 8 November 2021) revealed that these regulatory genes are frequently altered in different cancer types.