CHI3L1 and melanoma: Another study elucidated that chitinase 3-like 1 (CHI3L1), an enzymatically inactive mammalian chitinase, interacts with the extracellular matrix of melanoma cells, increasing the secretion of various cytokines, such as CCL2, and growth factors, such as vascular endothelial growth factor A (VEGF-A) [98].