Some interesting associations emerged between mutation occurrence and clinical manifestation of the disease, namely a strong association (rhopb = 0.93) between cholangiocarcinoma nodule size and the Notch pathway, and between liver disease etiology and genes IDH1 and ARID1A (phi = 0.82 and phi = 0.77 for HCV and HIV infection, respectively). This evidence concerns the gene IDH1 and HIV infectious disease.