TP53 and neuroblastoma: Neuroblastoma cell line sensitivity toward RITA spread between IC50 values 0.19 and >50 μM without any apparent clustering according to known cell line genetics, while sensitivity toward Nutlin-3 tended to be greater among TP53 wild-type neuroblastoma cell lines, with IC50 ranging between 0.47 and 16 μM (Figure 4B, Figure S3B and Table S2B).