TP53 and neuroblastoma: Although mutations of TP53 are not commonly detected at time of diagnosis in neuroblastoma or medulloblastoma, the p53 activity is recurrently compromised in these tumors [52,66,67,68,69], and p53 inactivation has been shown to contribute significantly to neuroblastoma and medulloblastoma development in specific animal models [70,71,72].