PDK4 and posterior cortical atrophy: Subsequent analyses of laser-microdissection-derived proteomes of human and murine prostate formalin-fixed paraffin-embedded tissue (FFPE) samples confirmed enhanced tricarboxylic acid cycle (TCA)/OXPHOS pathway proteins, which led to the identification of reduced pyruvate dehydrogenase kinase 4 (PDK4) gene expression, which is an essential regulator of TCA, as a promising independent prognostic risk-marker for PCa [17,18].