However, the concomitant use of the vaccine and tadalafil resulted in a decrease in PD-L1+ macrophages at the tumor edges, an intra-tumoral decrease in FoxP3+ T-regs, and an increase in intra-tumoral CD8+ CTLs associated with an augmentation of the CD69 early activation marker [97]. The gene discussed is FOXP3; the disease is neoplasm.