In addition to the well-studied cell-autonomous role of TET2 in tumor cells, our lab also revealed that the comprehensive knockout of Tet2 in mice leads to an impaired anti-tumor immunity due to the overactivation of granulocytic myeloid-derived suppressor cells (G-MDSCs) which subsequently decrease the number of cytotoxic CD8+ T cells [75]. This evidence concerns the gene TET2 and neoplasm.