Gao and colleagues [33] showed that NK cells can lose their anti-tumor properties by conversion into an intermediate type 1 innate lymphoid cells (intILC1s) (CD45+NKp46+CD49a+CD49b+) and type 1 innate lymphoid cells (ILC1s) (CD45+NKp46+CD49a+CD49b−). This evidence concerns the gene ITGA1 and neoplasm.