We observed an increased number of TAMs, neutrophils, and AMs, a low level of IFN-y, enhanced infiltration of CD4+ T cells, and a reduction in CD8+ cytotoxic T cells in non-tumor aneuploid areas of the lung implicating CIN in the development of an immunosuppressive environment. Here, CD4 is linked to cervical squamous intraepithelial neoplasia.