We next performed a cytokine array and found that the level of IFN-γ in the aneuploid group was significantly lower compared to control in both tumors and non-tumor areas (Figure S3e,f), suggesting a reduction in the cytolytic activity of NK cells despite their higher concentration, since IFN-γ is primarily secreted by activated T cells and NK cells [34]. This evidence concerns the gene IFNG and neoplasm.