Among those, the rearrangement between the Anaplastic lymphoma kinase (ALK) and the echinoderm microtubule-associated protein-like 4 (EML4) is identified in 3–7% of NSCLC cases, most commonly in younger patients, non-smokers, and those with adenocarcinoma histology [2]. Here, EML4 is linked to adenocarcinoma.