Remarkably, Kv11.1 silencing rescued the effects of NS1643 on both R-SMAD dephosphorylation and on inhibition of EMT markers synthesis, indicating that in the context of our colon cancer cell line system, the effects of NS1643 on TGFβ signaling was mainly mediated by Kv11.1. The gene discussed is KCNH2; the disease is colonic neoplasm.